• 描述
  A ready-to-use, high-yield E. coli-based cell-free protein synthesis system with built-in T7 RNA polymerase for rapid expression from T7-driven DNA or mRNA templates
• 图片:
  

  [3 Images]

• 抗原物种:
  Homo sapiens
• 描述
  The DDB1-CRBN complex is a crucial component of the E3 ubiquitin ligase system, specifically known as the DCX (DDB1-CUL4-X-box) E3 ubiquitin ligase complex, in which CRBN is the substrate recognition component. The complex tags specific proteins with ubiquitin molecules, signaling them for degradation. This process is essential for maintaining protein homeostasis within the cell.
• 图片:
  

  [2 Images]

• 抗原物种:
  Homo sapiens
• 描述
  The DDB1-DCAF12 complex is part of the CUL4-RBX1-DDB1-DCAF12 (CRL4DCAF12) E3 ubiquitin ligase complex of the DesCEND (destruction via C-end degrons) pathway. DCAF12 is the substrate recognition component of the complex, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation.
• 图片:
  

  [1 Image]

• 抗原物种:
  Homo sapiens
• 同义词:
  POLH
• 描述
  Low-fidelity DNA polymerase with a helicase activity that promotes microhomology-mediated end-joining (MMEJ), an alternative non-homologous end-joining (NHEJ) machinery required to repair double-strand breaks in DNA during mitosis. POLQ is often overexpressed in various cancers, especially those with HR deficiencies, such as BRCA1/2-mutated cancers.
• 图片:
  

  [2 Images]

• 抗原物种:
  Homo sapiens
• 同义词:
  Werner syndrome helicase, RECQ3, RECQL2, RECQL3, WRN RecQ like helicase, Werner syndrome RecQ like helicase
• 描述
  Multifunctional enzyme that has magnesium and ATP-dependent 3'-5' DNA-helicase activity on partially duplex substrates, and also 3'->5' exonuclease activity towards double-stranded (ds)DNA with a 5'-overhang. Binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and Holliday junctions. Plays a role in double-strand break repair after gamma-irradiation.
• 图片:
  

  [1 Image]

• 抗原物种:
  S. pyogenes
• 表达系统:
  Recombinant Cas9-based fusion with three NLS expressed by E.coli
• 描述
  PE7 is a fusion protein of the small RNA-binding protein La to the prime editor. Research indicates that PE7 has demonstrated substantial improvements in intended editing efficiencies across various cell lines and genomic loci compared to previous versions like PEmax. This development holds promise for a wide range of applications in both basic research and therapeutic settings.

• 抗原物种:
  S. pyogenes
• 表达系统:
  Recombinant Cas9-based fusion with double-ended NLS expressed by E.coli
• 描述
  PE2 is a revolutionary genome editing technology that allows for precise genetic modifications with minimal unintended effects. It integrates a Cas9-nickase fusion protein with a reverse transcriptase and a prime-editing guide RNA (pegRNA), enabling flexible editing capabilities.PE 2 represents a cutting-edge development in genome editing technology, offering significant advantages over traditional methods in terms of accuracy and versatility.​

• 抗原物种:
  S. pyogenes
• 表达系统:
  Recombinant Cas9-based fusion with three NLS expressed by E.coli
• 描述
  PE6b is a variant of the prime editor protein specifically designed for genome editing in living cells. It enhances the efficiency of genome edits compared to earlier versions of prime editors. Notably, editors like PE6b are smaller in size, allowing for more efficient delivery when used in medical and therapeutic applications.

1 Citations

• 抗原物种:
  Leptotrichia wadei
• 浓度
  4 mg/ml
• 描述
  GenCRISPR Cas13a (C2c2) Nuclease is an RNA-guided, RNA-targeting CRISPR enzyme, commonly referred to as C2c2. This enzyme is a member of Type VI CRISPR family containing a single protein effector with two HEPN domains. The Cas13a exhibits two RNase activities. The first activity, a cis- sequence-specific RNA guided cleavage, activates the secondary RNase activity of the enzyme, a non-specific trans- ribonuclease activity. This Cas13a protein can be applied to detect single RNA molecules with proven high specificity.
• 图片:
  

  [1 Image]

• 抗原物种:
  Leptotrichia buccalis
• 浓度
  4 mg/ml
• 描述
  GenCRISPR™ LbuCas13a Nuclease is an RNA-guided, RNA-targeting CRISPR enzyme, commonly referred to as LbuC2c2. This Cas13a protein can be applied to detect single RNA molecules with proven high specificity. Recently, Cas13a has been leveraged as a diagnostic nucleic acid detection tool.
• 图片:
  

  [1 Image]

• 抗原物种:
  S. pyogenes
• 表达系统:
  Recombinant Cas9 with an N-terminal NLS expressed by E.coli
• 浓度
  10 mg/mL
• 描述
  GenCRISPR™ Ultra Cas9 is produced by expression in an E. coli strain carrying a plasmid encoding the Cas9 gene from Streptococcus pyogenes with an N-terminal nuclear localization signal (NLS).
• 图片:
  

  [1 Image]

• 抗原物种:
  S. pyogenes
• 表达系统:
  Recombinant Cas9-based fusion with three NLS expressed by E.coli
• 描述
  PEmax RNase deletion involves modifications to the PEmax enzyme aimed at eliminating unwanted RNase activity, thus enhancing its stability and specificity. This advancement allows for more efficient target editing by minimizing the degradation of RNA components involved in the editing process, further improving the overall performance of the prime editing protocol.
• 图片:
  

  [2 Images]