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A Robust, High-Titer, Semi-Automated, and In-Culture Antibody-Capturing Transient CHO Platform Technology
Authors: Lauren Gebhardt, Molica Abel, Jing Zhou, Audrey M Vogt, Bo Hee Shin, Sarah L Herrick Wagman, Ana Santos, Jerome Puginier, Florian M Wurm, Maria J Wurm, Guoying Grace Yan, Adedolapo Adeniyi, Sean K H Lim, Will Somers, Laura Lin, Aaron M D'Antona, Xiaotian Zhong
Journal: Antibodies
PubMed ID: 41133681
Doi: 10.3390/antib 14040087
Human endogenous retrovirus K (HERV-K) envelope structures in pre- and postfusion by cryo-EM
Authors: Jeremy Shek; Chen Sun; Elise M. Wilson; Fatemeh Moadab; Kathryn M. Hastie; Roshan R. Rajamanickam; Patrick J. Penalosa; Stephanie S. Harkins; Diptiben Parekh; Chitra Hariharan; Dawid S. Zyla; Cassandra Yu; Kelly C. L. Shaffer; Victoria I. Lewis; Ruben Diaz Avalos; Tomas Mustelin; Erica Ollmann Saphire
Journal: SCIENCE ADVANCES
PubMed ID: 40864726
Doi: 10.1126/sciadv.ady8168
Modifying recombinant purple acid phosphatase using computational design
Authors: Aishwarya Venkatramani, Montader Ali, Olga Predeina, Jennifer C Molloy, Pietro Sormanni, Elizabeth A H Hall
Journal: European Biophysics Journal
PubMed ID: 40650743
Doi: 10.1007/s00249-025-01779-3
Lecanemab preferentially binds to smaller aggregates present at early Alzheimer's disease
Authors: Emre Fertan; Jeff Y. L. Lam; Giulia Albertini; Maarten Dewilde; Yunzhao Wu; Oluwatomi E. S. Akingbade; Dorothea B ken; Elizabeth A. English; Bart De Strooper; David Klenerman
Journal: Alzheimer's & Dementia
PubMed ID: 40237235
Doi: 10.1002/alz.70086
A humanised ACE2, TMPRSS2, and FCGRT mouse model reveals the protective efficacy of anti-receptor binding domain antibodies elicited by SARS-CoV-2 hybrid immunity
Authors: Fernanda Ana-Sosa-Batiz; Shailendra Kumar Verma; Norazizah Shafee; Robyn Miller; Chris Conner; Kathryn M. Hastie; Julia Timis; Erin Maule; Michael N. Nguyen; Linda Tran; Krithik Varghese; Henry Madany; Audrey Elizabeth Street; Michelle Zandonatti; Meng Ling Moi; Kurt Jarnagin; David R. Webb; Erica Ollmann Saphire; Kenneth Kim; Sujan Shresta
Journal: EBioMedicine
PubMed ID: 40020261
Doi: 10.1016/j.ebiom.2025.105619
Increasing brain half-life of antibodies by additional binding to myelin oligodendrocyte glycoprotein, a CNS specific protein
Authors: Marie-Lynn Cuypers; Tom Jaspers; Jarne Clerckx; Simon Leekens; Christopher Cawthorne; Guy Bormans; Frederik Cleeren; Nick Geukens; Bart De Strooper; Maarten Dewilde
Journal: Fluids and barriers of the CNS
PubMed ID: 39885527
Doi: 10.1186/s12987-025-00624-1
Cancer-associated polybromo-1 bromodomain 4 missense variants variably impact bromodomain ligand binding and cell growth suppression
Authors: Karina L. Bursch; Christopher J. Goetz; Guanming Jiao; Raymundo Nu ez; Michael D. Olp; Alisha Dhiman; Mallika Khurana; Michael T. Zimmermann; Raul A. Urrutia; Emily C. Dykhuizen; Brian C. Smith
Journal: The Journal of Biological Chemistry
PubMed ID: 38460939
Doi: 10.1016/j.jbc.2024.107146
Diverse array of neutralizing antibodies elicited upon Spike Ferritin Nanoparticle vaccination in rhesus macaques
Authors: Rajeshwer S Sankhala , Kerri G Lal , Jaime L Jensen , Vincent Dussupt , Letzibeth Mendez-Rivera , Hongjun Bai , Lindsay Wieczorek , Sandra V Mayer , Michelle Zemil , Danielle A Wagner , Samantha M Townsley , Agnes Hajduczki , William C Chang , Wei-Hung Chen , Gina C Donofrio , Ningbo Jian , Hannah A D King , Cynthia G Lorang , Elizabeth J Martinez , Phyllis A Rees , Caroline E Peterson , Fabian Schmidt , Tricia J Hart , Debra K Duso , Lawrence W Kummer , Sean P Casey , Jazmean K Williams , Shruthi Kannan , Bonnie M Slike , Lauren Smith , Isabella Swafford , Paul V Thomas , Ursula Tran , Jeffrey R Currier , Diane L Bolton , Edgar Davidson , Benjamin J Doranz , Theodora Hatziioannou , Paul D Bieniasz , Dominic Paquin-Proulx , William W Reiley , Morgane Rolland , Nancy J Sullivan , Sandhya Vasan , Natalie D Collins , Kayvon Modjarrad , Gregory D Gromowski , Victoria R Polonis , Nelson L Michael , Shelly J Krebs , M Gordon Joyce
Journal: Nat Commun
PubMed ID: 38172512
Doi: 10.1038/s41467-023-44265-0.
Potent Omicron-neutralizing antibodies isolated from a patient vaccinated 6 months before Omicron emergence
Authors: Kathryn M Hastie, Xiaoying Yu, Fernanda Ana-Sosa-Batiz, Dawid S Zyla, Stephanie S Harkins, Chitra Hariharan, Hal Wasserman, Michelle A Zandonatti, Robyn Miller, Erin Maule, Kenneth Kim, Kristen M Valentine, Sujan Shresta, Erica Ollmann Saphire
Journal: Cell Rep
PubMed ID: 37083327
Doi: 10.1016/j.celrep.2023.112421
Products & Services: Recombinant Proteins   
Molecular probes of spike ectodomain and its subdomains for SARS-CoV-2 variants, Alpha through Omicron
Authors: I-Ting Teng, Alexandra F Nazzari, Misook Choe, Tracy Liu, Matheus Oliveira de Souza, Yuliya Petrova, Yaroslav Tsybovsky, Shuishu Wang, Baoshan Zhang, Mykhaylo Artamonov, Bharat Madan, Aric Huang, Sheila N Lopez Acevedo, Xiaoli Pan, Tracy J Ruckwardt, Brandon J DeKosky, John R Mascola, John Misasi, Nancy J Sullivan, Tongqing Zhou, Peter D Kwong
Journal: PLoS ONE
PubMed ID: 35609088
Doi: 10.1101/2021.12.29.474491
Products & Services: Gene Synthesis   
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