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目录产品 » PVRIG hFc Chimera, Cynomolgus
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PVRIG hFc Chimera, Cynomolgus

PVRIG (poliovirus receptor related immunoglobulin domain-containing protein), also known as CD112 receptor (CD112R), is an approximately 34 kDa single transmembrane protein in the poliovirus receptor-like protein (PVR) family.PVRIG is a cell surface receptor for NECTIN2. May act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals. Following interaction with NECTIN2, inhibits T-cell proliferation. Competes with CD226 for NECTIN2-binding.
￥3600
Z04905-100

产品简介
Species Cynomolgus
Protein Construction
PVRIG (Thr41-Asp171)
Accession # A0A2K5WVV8-1		 hFc
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA.Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 40.3 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 50-60 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
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图例
PVRIG HFc Chimera, Cynomolgus

Immobilized PVRIG hFc Chimera, Cynomolgus, hFc Tag at 0.1 μg/ml (100 μl/well) on the plate. Dose response curve for Biotinylated Anti-PVRIG Antibody, hFc Tag with the EC50 of 4.8ng/ml determined by ELISA. »

PVRIG HFc Chimera, Cynomolgus

The purity of PVRIG hFc Chimera, Cynomolgus is greater than 95% as determined by SEC-HPLC. »

PVRIG HFc Chimera, Cynomolgus

PVRIG hFc Chimera, Cynomolgus on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

PVRIG HFc Chimera, Cynomolgus

PVRIG hFc Chimera, Cynomolgus, hFc Tag captured on CM5 Chip via Protein A can bind Human Nectin-2, His Tag with an affinity constant of 0.23 μM as determined in SPR assay (Biacore T200). »

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技术背景
Target Background PVRIG (poliovirus receptor related immunoglobulin domain-containing protein), also known as CD112 receptor (CD112R), is an approximately 34 kDa single transmembrane protein in the poliovirus receptor-like protein (PVR) family.PVRIG is a cell surface receptor for NECTIN2. May act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals. Following interaction with NECTIN2, inhibits T-cell proliferation. Competes with CD226 for NECTIN2-binding.
Synonyms C7orf15; CD112R; MGC104322; MGC138297; MGC2463; PVRIG; ALS2CR18; ALS2CR9; LPD; PREL-2; PREL2; RalGDS/AF-6; RMO1
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.