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目录产品 » GPVI, His, Cynomolgus
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GPVI, His, Cynomolgus

Although platelets are best known for their role in hemostasis, they are also crucial in development, host defense, inflammation, and tissue repair. Many of these roles are regulated by the immune-like receptors glycoprotein VI (GPVI) and C-type lectin receptor 2 (CLEC-2), which signal through an immunoreceptor tyrosine-based activation motif (ITAM). GPVI is activated by collagen in the subendothelial matrix, by fibrin and fibrinogen in the thrombus, and by a remarkable number of other ligands.
￥3500
Z04806-100

产品简介
Species Cynomolgus
Protein Construction
GPVI (Gln21-Asn251)
Accession # XP_005590417.2		 His
N-term C-term
Purity > 95% as determined by Bis-Tris PAGE
Endotoxin Level Less than 1 EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA.Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 26.42 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 50-60 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
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图例
GPVI, His, Cynomolgus

Immobilized GPVI, His, Cynomolgus, His Tag at 0.5 μg/ml (100 μl/well) on the plate. Dose response curve for Anti-GPVI Antibody, hFc Tag with the EC50 of 3.9ng/ml determined by ELISA. »

GPVI, His, Cynomolgus

The purity of GPVI, His, Cynomolgus is greater than 95% as determined by SEC-HPLC. »

GPVI, His, Cynomolgus

GPVI, His, Cynomolgus on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

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技术背景
Target Background Although platelets are best known for their role in hemostasis, they are also crucial in development, host defense, inflammation, and tissue repair. Many of these roles are regulated by the immune-like receptors glycoprotein VI (GPVI) and C-type lectin receptor 2 (CLEC-2), which signal through an immunoreceptor tyrosine-based activation motif (ITAM). GPVI is activated by collagen in the subendothelial matrix, by fibrin and fibrinogen in the thrombus, and by a remarkable number of other ligands.
Synonyms GPVI; Gp6; Glycoprotein 6; MGC138168
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.