GMP Anti-Human CD3 Antibody (OKT3), mAb, Mouse
This product is specific for Human CD3
| 询价 | |
| GMPA02199-100 | |
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| 询价 | |
| GMPA02199-100 | |
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| Specificity | This product is specific for Human CD3 |
| Host Species | Mouse |
| Immunogen | Recombinant Human CD3 |
| Conjugate | Unconjugated |
| ex vivo cell culture process; Flow cytometry |
GMP Anti-Human CD3 Antibody (OKT3), mAb, Mouse (Cat. No. GMPA02199) was used for primary T cell activation together with anti-Human CD28 antibody. The percentage of activated T cells was measured by flow cytometry. Data showed that GenScript GMP Anti-Human CD3 Antibody (OKT3), mAb, Mouse outperformed the competing products in activating primary T cells. »
Jurkat/IL-2-Luc Promoter cells were co-stimulated with a serial of concentrations of GMP Anti-Human CD3 Antibody (OKT3), mAb, Mouse (Cat. No. GMPA02199) and GMP Anti-Human CD28 Antibody (F105), mAb, Mouse (Cat. No. GMPA02213) for 6 h. Receptor-mediated signaling induced luminescence via the activation of the IL-2 pathway. »
| 外观 | Clear, colorless liquid |
| pH | 5.0 ± 0.5 |
| Concentration | 5.0 ± 0.5 mg/ml tested by A280 nm |
| Purity | ≥ 95.0% as analyzed by SEC-HPLC |
| Sequence | The coverage of the light chain and heavy chain sequence was 100% consistent with the theoretical amino acid sequence by mass spectrometry (MS) |
| Residual HCP | ≤ 100.0 ng/mg by ELISA method |
| Residual HCD | ≤ 10.0 pg/mg by quantitative PCR method |
| Residual Protein A | ≤ 10.0 ng/mg by ELISA method |
| Endotoxin Level | < 0.1 EU/mg by gel clotting method |
| Sterility | No growth |
| Reactivity | Qualified |
| Target Background |
CD3 is a member of the
immunoglobulin superfamily, expressed on T cells. It is composed of four
distinct chains (ε, γ, δ, ζ). CD3 antigen can form a complex with the T cell
receptor (TCR) to generate an activation signal in T cells, which plays an
important role in the transduction of TCR signal and the activation of both
cytotoxic T cells (CD8 + naïve T cells) and T helper cells (CD4+ naïve T cells). |
For laboratory research
and ex vivo cell isolation and
culture applications. Direct human use, including taking orally and injection
and clinical use are forbidden.
